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| Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa. |
| Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155 |
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| Freitas,RS; Carvalho-Vivi,JO; Zamboni,IM; Assis,CM; Costa-Martins,JE; Vicentini-Moreira,AP. |
| Histoplasmosis is a systemic mycosis caused by inhalation of Histoplasma capsulatum microconidia. The disease does not normally affect immunocompetent individuals after a single, transient inhalation exposure. However, longer exposure may cause chronic or disseminated acute pulmonary infection. Herein, we report the case of a 24-year-old immunocompetent patient, who presented fever, cough and dyspnea for one month. The chest radiography revealed interstitial infiltrate and diffuse micronodules. The patient reported having had close and prolonged contact with bats. Diagnosis was confirmed by positive double immunodifusion and immunoblotting assays. She was treated with ketoconazole (400 mg) and there was complete resolution of the disease. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histoplasmosis; Histoplasma capsulatum; Immunocompetence; Serodiagnosis; Bats. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200010 |
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